The International Microbiome and Multi-Omics Standards Alliance (IMMSA) is an open consortium of microbiome-focused researchers from industry, academia, and government. IMMSA was formed for the mutual benefit of the entire microbiome scientific community and will focus specifically on coordinating cross-cutting efforts that address microbiome measurement challenges. IMMSA members are representative experts for all major microbiological ecosystems (e.g. human/animal, built, and environmental ecosystems) and are representative experts from various scientific disciplines including microbiology, bioinformatics, genomics, metagenomics, proteomics, metabolomics, transcriptomics, epidemiology, and statistics. This will naturally expand as the science evolves. While remaining non-hierarchical, IMMSA will consist of a steering committee that oversees the activities of the consortium and implements the major directives of the consortium.